In Padua he studied mathematics, physics, astronomy, medicine, ancient philosophy and law; later in Cologne theology.
As a priest and scientist he rose to the highest ranks of public life of his time: Council member in Basel, papal legate in Germany, Cardinal, Bishop of Brixen and Vicar General in Rome.
As Curia Cardinal and advisor to Pope Pius II, he was concerned with the reform of the clergy and general church reform.
He was considered a serious candidate for the papal election, but died in 1464 in Todi, Umbria. His tomb is in the church of San Pietro in Vincoli in Rome. His heart rests in the chapel of the St. Nicholas Hospital donated by him.