The world-famous philosopher, mystic, natural scientist and cardinal was born here in 1401. His birthplace contains the permanent exhibition "Nikolaus von Kues, 1401 - 1464, - Leben und Werk im Bild", a documentation by Dr. Helmut Gestrich in cooperation with the "Landesbildstelle Rheinland-Pfalz" and the "Cusanus-Gesellschaft Bernkastel-Kues". The exhibition informs about the origin of St. Nicholas of Cues, his studies and education and his public work, as well as about his St. Nicholas Hospital as a visible and his writings as a spiritual heritage. The presentation of his life stations as well as his great legation journey 1451/52 by Professor Erich Meuthen, the globe game, the foundation deed of the hospital and numerous facsimile writings complete the documentation.
In this house he completed his major philosophical work "De docta ignorantia" on February 12, 1440, a work that stands like a landmark between the Middle Ages and modern times. It replaced medieval theology and its geocentric world view with a new interpretation of world construction. This even went beyond Copernicus, Galileo and Kepler and proved to be true in the light of the modern astrophysics of Albert Einstein. The rooms of the birthplace serve the cultural life of our time: art exhibitions, religious talks, lectures, music and also celebrations from various occasions take place here.